Tag Archive for ‘clinical trials’
Clinical Trial Examines Postoperative Chemotherapy versus Observation in High-Risk Pancreatic Neuroendocrine Tumors
The S2104 trial compares chemotherapy to observation following resection of pancreatic neuroendocrine tumors.
Prophylactic hyperthermic intraperitoneal chemotherapy in gastric cancer
Gastric cancer is an aggressive malignancy with poor overall survival rates as a result, in part, of its predilection for peritoneal dissemination. Peritoneal metastasis (PM) is found in up to 55 to 60 percent of patients at the time of diagnosis by imaging or staging laparoscopy.1,2 In addition, despite multimodality therapy, peritoneal recurrence occurs in […]
New trial aims to settle debate on the intensity of pancreatic cyst surveillance
Pancreatic cystic neoplasms occur in up to 20 percent of the U.S. adult population, and the incidence increases with more advanced age.1 In recent years, the prevalence of cystic neoplasms of the pancreas appears to be increasing as more patients undergo cross-sectional imaging in both the ambulatory and emergency setting. A recent study of patients […]
Ga-68 imaging changes clinical management of GI and pancreatic neuroendocrine tumors
Ga-68 positron emission tomography has improved the clinical management of gastrointestinal and pancreatic neuroendocrine tumors, and multiple studies are ongoing to define its optimal role in clinical practice.
Databases: Where math meets medicine
Balancing statistical relevance with clinician experience leads to innovative approaches to patient care.
The evolution of lung cancer surgery contributes to the sharpest drop in overall cancer mortality in the U.S.
This article describes the advancements in early detection and surgical treatment of lung cancer that led to improved lung cancer survival from a thoracic surgeon’s perspective.
Early-stage prostate cancer decision aids for diverse patient populations
The aim of the Alliance A191402CD trial is to evaluate the use of decision aids for men choosing treatment for located prostate cancer, particularly in minority populations.
What is the National Clinical Trials Network, and how do I join?
A summary of the structure and function of the National Cancer Institute’s National Clinical Trial Network is provided.
Modified FOLFIRINOX is superior to gemcitabine as adjuvant therapy for resected pancreatic cancer: The PRODIGE 24/CCTG PA6 Trial
The study design and findings of the PRODIGE 24/CCTG PA6 Trial are outlined, which showed improved survival with modified FOLFIRINOX for resected pancreatic cancer patients.
ALCHEMIST trial has potential to improve outcomes after lung cancer resection
The ALCHEMIST CHEMO-IO is a trial for patients with early-stage non-small cell lung cancer (NSCLC) with the potential to change the way patients with resected NSCLC are treated.
Could axillary reverse mapping be useful in reducing surgical comorbidities?
A summary of some of the research that evaluates the role of axillary reverse mapping in cancer patients.
Evolution in the management of desmoid tumors: Challenging the role of upfront surgical resection
Describes the traditional management of desmoid tumors as well as new approaches, including radiation therapy for locally aggressive tumors.
Opportunities at Clinical Congress 2019 to increase surgeon participation in clinical research
The ACS CRP will offer sessions at Clinical Congress 2019 on the topics of developing clinical trial and decreasing administrative burden associated with those trials.
Defining the optimal treatment of locally advanced gastric cancer
Clinical trial data are examined to help develop a consensus approach for locally advanced gastric cancer.
Preoperative smoking intervention techniques improve outcomes for lung cancer patients
Smoking cessation intervention trials examine potential outcome improvements for lung cancer patients.
Atezolizumab in the adjuvant treatment of stage III colon cancer: Can PD-L1 inhibition improve survival?
The study design for the ATOMIC trial (Alliance A021502), a randomized phase III study examining atezolizumab treatment of stage III colon cancer, is described.
Robotic surgery for hepatic neoplasms: Where does it fit in the minimally invasive surgery landscape?
This month’s column identifies prospective clinical trials aimed at clarifying the role of laparoscopic and robotic surgery for hepatic neoplasms.
Active surveillance as a treatment modality in ductal carcinoma in situ
Because many cases of ductal carcinoma in situ (DCIS) may remain stable without excision, more clinical trials are exploring the role of active surveillance in DCIS management.
Immunotherapy in solid tumors
The role of precision immunotherapy in treating solid tumors is summarized.
Clinical trials for surgeons: Hurdles and opportunities
An educational program developed jointly by the ACS CRP and the Society of Surgical Oncology provides surgeons with the tools they need to actively participate in clinical trials