Tag Archive for ‘clinical trial’

Clinical trial for patients with incidentally discovered T2 or T3 gallbladder cancer: OPT-IN/EA2197

Describes the aim and structure of the OPT-IN trial, which was developed to address the high recurrence rates seen in patients with presumably localized disease after re-resection of incidentally diagnosed gallbladder cancer.

Neoadjuvant immunotherapy: Results in melanoma show promise and pave the way for other solid tumors

It is astonishing to consider that it was only 10 years ago that the first immune checkpoint blockade inhibitor garnered Food and Drug Administration approval. Modern immunotherapy began as single-agent therapy in patients with widely metastatic disease in just a few types of cancer, whereas today, hundreds of different agents targeting various aspects of the […]

Trials explore whether endocrine therapy can delay or avert surgery in low-risk DCIS

Over the last several decades, the widespread implementation and uptake of screening mammography has contributed to earlier diagnosis of breast cancer and improvements in breast cancer mortality. However, the screening has led to a significant rise in the detection of ductal carcinoma in situ (DCIS), which is a pre-cancer of the breast. Much like invasive […]

Preoperative radiotherapy for retroperitoneal sarcoma: Where do we go from here?

The role of radiation therapy (RT) in the management of retroperitoneal sarcomas has been a longstanding topic of debate among physicians, and institutional and individual preferences have led to significant variability and inconsistencies in its use.1 The presumed benefit of RT in the management of retroperitoneal sarcomas has been inferred from its local control benefit […]


Organ preservation in rectal adenocarcinoma: The OPRA Trial

The study design of the OPRA Trial, which includes a watch-and-wait cohort for locally advanced rectal cancer, is summarized.


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