Tag Archive for ‘clinical trials’

ACS CRP

Atezolizumab in the adjuvant treatment of stage III colon cancer: Can PD-L1 inhibition improve survival?

The study design for the ATOMIC trial (Alliance A021502), a randomized phase III study examining atezolizumab treatment of stage III colon cancer, is described.

ACS CRP

Robotic surgery for hepatic neoplasms: Where does it fit in the minimally invasive surgery landscape?

This month’s column identifies prospective clinical trials aimed at clarifying the role of laparoscopic and robotic surgery for hepatic neoplasms.

NCDB logo

Active surveillance as a treatment modality in ductal carcinoma in situ

Because many cases of ductal carcinoma in situ (DCIS) may remain stable without excision, more clinical trials are exploring the role of active surveillance in DCIS management.

ACS CRP

Immunotherapy in solid tumors

The role of precision immunotherapy in treating solid tumors is summarized.

ACS CRP

Clinical trials for surgeons: Hurdles and opportunities

An educational program developed jointly by the ACS CRP and the Society of Surgical Oncology provides surgeons with the tools they need to actively participate in clinical trials

Figure 1. Mechanism of checkpoint blockade

Current role of immunotherapy in urologic cancers

The role of immunotherapy in the treatment of urologic cancers is summarized and the efficacy of novel immunotherapeutics, particularly checkpoint inhibitors, are described, which may hold promise for a wide variety of tumor types.

ACS CRP

Gastrectomy for cancer: What are the benefits of a minimally invasive approach?

Gastric cancer is a significant cause of cancer morbidity and mortality in the U.S., with an estimated 26,370 new cases and 10,730 deaths in 2016.1 The incidence of gastric cancer is rising, particularly proximal tumors, and among young (< 40 years old) Caucasians, who have experienced a nearly 70 percent increase in the incidence of […]

ACS CRP

ACS CRP Dissemination and Implementation Committee issues call for participants in pilot project

The mission of the Dissemination and Implementation Committee—to provide surgeons with practice-changing results of the Alliance and other national clinical trial groups—is summarized.

Figure 1. Prostate cancer choice tool

Interventions to promote better conversations about initial treatment for prostate cancer

Decision aids to enhance conversations with minority males entering prostate cancer treatment are described.

ACS Clinical Research Program

Junior investigators: Get engaged in the Alliance for Clinical Trials in Oncology

Strategies for enhancing junior investigator participation in Alliance programs are highlighted.

Improving rectal cancer outcomes through advocacy, education, and research: The OSTRiCh Consortium and the new NAPRC

Over the last three decades, there has been a significant shift in cancer care from the generalist to the specialist setting. This shift is especially true in surgical oncology, where surgeons specializing in the care of breast cancer, esophageal cancer, and pancreatic cancer have become the norm for many facilities treating cancer patients in the […]

Figure 1. NRG Oncology NRG-GI002 Schema

NRG GI002: Moving the needle toward TNT in locally advanced rectal cancer

The approach, aims, and eligibility criteria of the NRG Oncology TNT clinical trial are summarized.

Why is surgeon qualification important for clinical trials, and how can it be achieved?

This month’s column underscores the importance of clinical trial participation, in particular surgeons who have a demonstrated capability and knowledge in conducting research-related operations.

Figure 1. Schema for SWOG Trial 1505

Two studies pave the way for preoperative therapy in pancreatic cancer patients

Pancreatic cancer is the fourth-most common cause of cancer-related death in the U.S. and is predicted to soon be the third-leading cause. Surgical resection with pancreatectomy has historically been viewed as offering the only chance for cure. However, achieving negative margins at surgery can be difficult, with positive surgical margins found in as many as […]

Figure 1. SWOG S1316 Schema

Prospective comparative effectiveness trial for malignant bowel obstruction: SWOG S1316

The aim and approach of the Prospective Comparative Effectiveness Trial for Malignant Bowel Obstruction trial is the focus of this month’s column.

Response to preoperative endocrine therapy in breast cancer patients can alter surgical and chemotherapy options

The uptake of neoadjuvant endocrine therapy in the U.S. has been slow according to the authors of this month’s column, even though this treatment can reduce the extent of breast surgery.

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Improving resection rates in borderline resectable pancreatic cancer: Pilot study shows favorable results

The clinical importance of the Alliance A021101 cooperative group study as well as the design of the trial itself are the focus of this month’s column.

Figure 1. ALCHEMIST schema

Biomarker-driven adjuvant targeted therapy for NSCLC—the ALCHEMIST trials

This month’s column summarizes the ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials) platform and how it facilities definitive studies of adjuvant targeted therapies in biomarker-selected non-small cell lung cancer patients.

Multimodality treatment considerations in esophageal and gastric cancer: Are we making progress?

This column addresses the efficacy of combining existing approaches with active therapeutic combinations to treat cancers of the stomach and esophagus.

Alliance for Clinical Trials in Oncology

Limited resection as a cure for early lung cancer: Time to challenge the gold standard?

A clinical trial is exploring whether limited resection should replace lobectomy as the gold standard for treatment of early-stage lung cancer.

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