Tag Archive for ‘clinical trials’

Figure 1. Mechanism of checkpoint blockade

Current role of immunotherapy in urologic cancers

The role of immunotherapy in the treatment of urologic cancers is summarized and the efficacy of novel immunotherapeutics, particularly checkpoint inhibitors, are described, which may hold promise for a wide variety of tumor types.

ACS CRP

Gastrectomy for cancer: What are the benefits of a minimally invasive approach?

Gastric cancer is a significant cause of cancer morbidity and mortality in the U.S., with an estimated 26,370 new cases and 10,730 deaths in 2016.1 The incidence of gastric cancer is rising, particularly proximal tumors, and among young (< 40 years old) Caucasians, who have experienced a nearly 70 percent increase in the incidence of […]

ACS CRP

ACS CRP Dissemination and Implementation Committee issues call for participants in pilot project

The mission of the Dissemination and Implementation Committee—to provide surgeons with practice-changing results of the Alliance and other national clinical trial groups—is summarized.

Figure 1. Prostate cancer choice tool

Interventions to promote better conversations about initial treatment for prostate cancer

Decision aids to enhance conversations with minority males entering prostate cancer treatment are described.

ACS Clinical Research Program

Junior investigators: Get engaged in the Alliance for Clinical Trials in Oncology

Strategies for enhancing junior investigator participation in Alliance programs are highlighted.

Improving rectal cancer outcomes through advocacy, education, and research: The OSTRiCh Consortium and the new NAPRC

Over the last three decades, there has been a significant shift in cancer care from the generalist to the specialist setting. This shift is especially true in surgical oncology, where surgeons specializing in the care of breast cancer, esophageal cancer, and pancreatic cancer have become the norm for many facilities treating cancer patients in the […]

Figure 1. NRG Oncology NRG-GI002 Schema

NRG GI002: Moving the needle toward TNT in locally advanced rectal cancer

The approach, aims, and eligibility criteria of the NRG Oncology TNT clinical trial are summarized.

Why is surgeon qualification important for clinical trials, and how can it be achieved?

This month’s column underscores the importance of clinical trial participation, in particular surgeons who have a demonstrated capability and knowledge in conducting research-related operations.

Figure 1. Schema for SWOG Trial 1505

Two studies pave the way for preoperative therapy in pancreatic cancer patients

Pancreatic cancer is the fourth-most common cause of cancer-related death in the U.S. and is predicted to soon be the third-leading cause. Surgical resection with pancreatectomy has historically been viewed as offering the only chance for cure. However, achieving negative margins at surgery can be difficult, with positive surgical margins found in as many as […]

Figure 1. SWOG S1316 Schema

Prospective comparative effectiveness trial for malignant bowel obstruction: SWOG S1316

The aim and approach of the Prospective Comparative Effectiveness Trial for Malignant Bowel Obstruction trial is the focus of this month’s column.

Response to preoperative endocrine therapy in breast cancer patients can alter surgical and chemotherapy options

The uptake of neoadjuvant endocrine therapy in the U.S. has been slow according to the authors of this month’s column, even though this treatment can reduce the extent of breast surgery.

figure 1

Improving resection rates in borderline resectable pancreatic cancer: Pilot study shows favorable results

The clinical importance of the Alliance A021101 cooperative group study as well as the design of the trial itself are the focus of this month’s column.

Figure 1. ALCHEMIST schema

Biomarker-driven adjuvant targeted therapy for NSCLC—the ALCHEMIST trials

This month’s column summarizes the ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials) platform and how it facilities definitive studies of adjuvant targeted therapies in biomarker-selected non-small cell lung cancer patients.

dispatches-table

Multimodality treatment considerations in esophageal and gastric cancer: Are we making progress?

This column addresses the efficacy of combining existing approaches with active therapeutic combinations to treat cancers of the stomach and esophagus.

Alliance for Clinical Trials in Oncology

Limited resection as a cure for early lung cancer: Time to challenge the gold standard?

A clinical trial is exploring whether limited resection should replace lobectomy as the gold standard for treatment of early-stage lung cancer.

Industry-sponsored clinical trials: The problem of conflicts of interest

This article presents a case study involving an ethical dilemma in which a pharmaceutical company asks a physician to participate in a clinical trial and offers to pay the physician for enrolling patients in the study. The authors explore four options for resolving the dilemma: accept the offer and only reveal details relevant to informed consent, accept the offer and inform patients of the reimbursement arrangement, participate in the clinical trial without accepting reimbursement, and avoid participating in the clinical trial altogether.

alliance logo CMYK

Are older adults adequately represented in surgical oncology trials?

Older adults are projected to comprise a significant portion of a surgeon’s patient population. However, current surgical oncology trials are not designed to allow for widespread generalizability to their practice. This column features insights into the gap between cancer trials and the real world and the potential role of Z901101 in stimulating future studies and polices to broaden the accrual of older adults and their surgeons in new oncology trials.

Figure 1: Treatment schema for patients with borderline resectable pancreatic cancer2

Borderline resectable pancreatic cancer: Pushing the technical limits of surgery

This column discusses how multimodality therapy, including surgical resection, now represents a potential route to long-term survival for a group of patients with so-called “borderline resectable” cancers.

Z11102 trial schema

Multiple ipsilateral breast cancers: Can the breast be preserved?

ACOSOG Z11102 is a recently activated Alliance for Clinical Trials in Oncology study that will determine prospectively whether breast conservation is a safe surgical approach for patients with multiple ipsilateral breast cancers. This trial is the first prospective look at this increasingly common clinical scenario, and results will provide important data that surgeons and radiation oncologists may use to inform patients regarding surgical treatment options.

Malignant pleural effusion research provides insights to improve surgical study design

Our research shows tunneled pleural catheters are reliable methods to control malignant pleural effusion and may be optimal if full lung expansion is uncertain. This experience also suggested that a phased data gathering approach to better launch complex surgical trials and the selective use of alternative trial designs would enhance such future endeavors. This column highlights important lessons for future study.

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